Stem cells can be obtained from several sources, and each source has its
ADVANTAGES and DISADVANTAGES. So let’s explore which source of stem cells will not only get you the best results, but is safe and FDA-approved.
Stem cells can be broadly considered to be sourced 3 ways: allogenically, autogenically and xenogenically. The source of cells utilized can be autologous, meaning from the patient himself, allogenic, meaning from a human donor not immunologically identical, or xenogenic, meaning from a different species. Allogenic sources include placental, umbilical cord, and embryonic tissue; autogenic sources are principally bone marrow and adipose tissue.
EMBRYONIC STEM CELLS
Human embryonic stem cells (HESCs) are very potent and very effective in their capability to differentiate into various types of tissue. However, they are derived from fetal tissue (prior to conception or from dead fetal matter) and therefore brings with it MORAL and ETHICAL ISSUES.
These ethical concerns surrounding sourcing results in a very limited supply of these cells. With a limited supply of embryonic stem cells, extensive in vitro (made in a laboratory) expansion would be required to obtain a sufficient number of cells for therapeutic purposes. Therefore, HESCs have been mostly derived and cultured on a layer of mouse embryonic fibroblasts (MEFs). The concern over xenogenic (from an animal) contaminants from the mouse feeder cells may be a limiting factor for transplantation to humans.
Furthermore, these HESC’s have been shown to cause tumors (CANCER) in the tissues.
WHY WE DO NOT RECOMMEND HESCs:
MORAL and ETHICAL DILEMMA
CAN CAUSE CANCER
CONTAMINATION
ADULT STEM CELLS
Adult stem cells have the advantage of being non-immunogenic (no allergic reactions). They are currently in wide use for a broad range of clinical applications. These cells are usually derived from autologous (from patient) bone marrow or fat cells, which are extracted in one procedure, isolated, treated and amplified, and then reinserted to the target pathological area through another interventional procedure.
There exists a wide variety of methods by which the cells are isolated, treated and amplified. These can vary even from procedure to procedure within a single clinic. Most of these processes are proprietary, and many are protected by patent. As a result, there is no simple way to determine if a procedure or a particular application has clinical validity. Much of the information available takes on an air of being anecdotal, and resistant to investigation through rigorous scientific method. Most, if not all, of the current clinical use of adult stem cells in the United States would fall under this rather inauspicious descriptor.
Besides the fact that the use of adult stem cells is non-standardized, and there’s no uniformity and no quality control, the application requires a surgical intervention to harvest the stem cells. This surgical intervention increases risk (as with any surgery) and increases the cost to the patient.
Furthermore, the results are NOT CONSISTENT. That’s because these adult stem cells may lack the 3 essential components necessary for a successful treatment: Growth factors (GF’s), Bio-molecules and collagen scaffold (the activator, the tools and the plan). In addition, we already established that the number of adult stem cells drastically declines with age, so often not enough healthy cells can be harvested.
WHY WE DO NOT RECOMMEND ADULT STEM CELLS:
Requires SURGERY (increases RISK and COST)
INCONSISTENT RESULTS
NOT ENOUGH HEALTHY CELLS AVAILABLE (age)
NO QUALITY CONTROL
NOT STANDARDIZED (not FDA approved)
PLACENTAL TISSUE MATRIX
Using placental tissue as a source of stem cells, derived from the placenta of healthy and screened U.S. women after a C-section delivery (donors are free of disease), is by far your best option.
The placenta contains approximately 100 million AEC’s (amniotic epithelial cells) which have all the properties of stem cells. So we don’t have to worry about the amount of stem cells, also knowing that they have the ability to self-replicate.
Even more importantly, and unlike other sources of stem cells (with the exception of umbilical cord), placenta tissue contains all 3 key components necessary for effective and consistent repair and regeneration of connective tissue:
Growth Factors (GF’s): to activate the stem cells,
Bio-molecules: to provide the tools (brick and mortar) necessary for repair and rebuilding connective tissue,
Collagen scaffold: to provide the structure and framework (blueprint) for optimal reconstruction and regeneration of connective tissue.
In addition, placental tissue is non-immunogenic, anti-inflammatory, and anti-microbial. No moral and ethical issues exist.
The procurement and procedure (harvesting, processing and sterilization, storage and distribution) of the placenta is conducted under strict FDA-guidelines.
WHY WE DO RECOMMEND PLACENTA TISSUE MATRIX:
NO SURGERY
AMPLE HEALTHY STEM CELLS
ALL KEY COMPONENTS AVAILABLE (GF’s, biomolecules, collagen scaffold)
REDUCES PAIN & INFLAMMATION
VERY EFFECTIVE, NO ADVERSE REACTIONS, MINIMAL DOWNTIME
100% SAFE & FDA-APPROVED
COST-EFFECTIVE
STEM CELL SOURCES POSITIVE
STEM CELL SOURCES NEGATIVE
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